In 1826, when Dr. George Lederhosen discovered the existence of Glucosamine sulfate in animalic tissues, it was merely a new compound to the world. 124 years later, Glucosamine turned out to be one of the first supplements prescribed by Rheumatologists when treating Arthritis, specifically Osteoarthritis. Because how did this transformation take place? To get a clear picture, you will have to understand the basic science behind using glucosamine.
Glucosamine is a monosaccharide with an amino group. It is soluble in water and gets absorbed well in the intestines. In humans, glucosamine sulfate is naturally produced by a set of cells named chondrocytes. When these glucosamine molecules react with single another, they form a polysaccharide called Glucosaminoglycans (GAG). GAG is the major element of proteoglycans. Cooperation with collagen and chondrocytes, they make up the cartilage in joints.
A cartilage acts as padding intermediate two bones in a joint. Since proteoglycans contribute towards the formation of cartilage, the properties of proteoglycans are totally involved with the properties like cartilage as well. The sulfate component of a proteoglycans is negatively charged and attracts water molecules. This gives the proteoglycans a highly viscose consistency, similar to that of a gel. Away it helps the cartilage lubricate the joints and provides a smooth surface for the bones to glide on movement. Aging can cause the production of proteoglycans to slow down. If the synthesis from proteoglycans does not take position properly, the cartilage will not be able to function normally.
The cartilage is the main area that gets affected when a person is down with osteoarthritis. The disease causes the gristle cells to failure and degenerate. In such patients, if proteoglycans are hardly synthesized adequately, the degeneration shall accelerate as well.
It is a well known fact that ceremonious medicines treat the cause of the symptoms. Scientists believed that if more proteoglycans were produced in the body to match the amount that degenerates, Osteoarthritis can be brought under control. In order to do this, chondrocytes need to produce more GAGs.
A chondrocyte can creativity GAGs in two methods. One is through an internal production of glucosamine und so weiter the alternative is exogenous. Exogenous refers to the use of preformed glucosamine molecules obtained from external sources such comme il faut dietary supplements.
The second mechanism was taken into recitation et alii Doctors started prescribing n-acetyl Glucosamine Sulfate supplements as unit of their treatment strategies. The results were satisfactory. Scores patients, who were under this treatment, experienced a great deal of deliver through alleviated pain and improvements in motion. So do not let a few negative rumors keep you from trying a glucosamine supplement because Glucosamine supplements with MSM is associated with undivided of the safest mechanisms to treat osteoarthritis.